Japanese researchers use iPS cells to culture cells that can differentiate into eggs.

:2018-09-25

Xinhua News Agency, Tokyo, September 24 - Researchers at Kyoto University in Japan have announced that they have successfully used human-induced pluripotent stem cells (iPS cells) to successfully culture oogonia cells that can differentiate into eggs. The results of this research are expected to be used to study the causes of infertility and some hereditary diseases.

Previously, researchers at Kyoto University have successfully used human iPS cells to culture primordial germ cells. Primordial germ cells are early cells that produce male and female germ cells.

After approval by the Kyoto University Ethics Committee, researchers at Kyoto University first used human iPS cells to culture primordial germ cells, which were then cultured with a large number of ovary cells extracted from experimental mouse embryos to obtain oogonia cells.

Opiocytes are the next stage of differentiation of primordial germ cells, which can be further differentiated to form eggs. However, the use of oogonia cells to culture eggs requires the reproduction of the human ovarian environment, so this study has not been able to produce eggs.

Researchers say that artificially cultured oogonia cells can be used to study the causes of infertility and some hereditary diseases. The research results have been published in the electronic version of the new US Science magazine.

iPS cells are stem cells with strong differentiation potential, which are formed by genetically modified "induction" of somatic cells such as skin cells. Previously, Japanese researchers used iPS cells to grow eggs from experimental mice and obtained healthy mice by artificial insemination. Due to ethical issues, Japan does not allow insemination experiments with sperm and eggs cultured from human iPS cells. (Reporter Huayi)

Source: Xinhua News Agency

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